报告人：Gregory B. Dudley
报告题目：Chemical synthesis: enabling technology andenigmatic challenge
GregoryB. Dudley is the Eberly Family Distinguished Professor of Chemistry andDepartment Chair of the C. Eugene Bennett Department of Chemistry at WestVirginia University in Morgantown, WV. Prof Dudley received a B.A. from FSU in1995 and a Ph.D. from MIT in 2000 under the direction of Prof. Rick Danheiser.After receiving an NIH Postdoctoral Fellowship to work with Prof. SamuelDanishefsky at the Sloan–Kettering Institute for Cancer Research, he returnedto FSU as an Assistant Professor in 2002. He was promoted to the rank ofAssociate Professor with tenure in 2008 and to Full Professor in 2015 beforemoving to WVU in July 2016. Professor Dudley has been recognized with awardsfor innovation, scholarship, and classroom teaching. Research efforts in hisindependent career have resulted in over 70 publications, 160 presentations,and multiple patents related to two commercial products. The current mission of his research programis to impact the drug discovery and development processes by contributing fundamentalknowledge in organic chemistry, including new strategies, tactics, and researchtools for best practices in organic synthesis.
Research in the Dudley Lab isdesigned to further the science and practice of organic chemistry. This seminarwill cover two disparate topics linked by a focus on expanding the power ofchemical synthesis, an enabling technology for all of the molecular sciences.The first part features “alkynogenic fragmentation” methodology: C–Cbond-cleaving anionic fragmentation reactions that generate alkynes. It focuseson alkyne chemistry in the context of important problems in the chemicalsynthesis of bioactive natural products. The second part of the seminaraddresses enigmas surrounding the use of microwave electromagnetic radiation topromote thermal chemical reactions. Organic reaction mixtures are typicallyheated convectively, and the physics of convective heat transfer underlies allof physical organic theory. Microwave energy, in contrast, produces heat byfundamentally different mechanisms, which need to be understood in order for usto gain maximum benefit from this new technology. Examples and a physical modelfor selective heating in solution will be presented and discussed.